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The successful scientist will work with colleagues throughout BMS to establish assays using immunohistochemistry, multiplex staining/imaging, in situ nucleic acid hybridization, and digital pathology. The scientist will be directly responsible for the design, development, execution, and analysis of translational tissue-based biomarker assays to interrogate target prevalence, target engagement, mechanisms of action, pharmacokinetics, pharmacodynamics, -and prediction of treatment response. The position entails working on projects independently and in multi-disciplinary teams consisting of pathologists, lab scientists, data scientists and clinical biomarker scientists. The IHC scientist will develop tissue-based assays for internal or external use with accountability for assays transferred to partner labs and contract research organizations (CROs). The scientist will also be responsible for working with digital pathology colleagues to build and assess image analysis algorithms and workflows.
The successful scientist must have strong technical experience in IHC assay development using several platforms and techniques and a working knowledge of histology/morphology/pathology interpretation relevant to assay development. The scientist must show strong communication and organizational skills, the ability to work collaboratively with other team members, adaptability to regulated work environments and the flexibility to accommodate changing business needs.
Required Skills/Qualifications:
- A bachelor's degree is required. An advanced degree (MS, PhD) in biological sciences or a related biomedical field will be helpful
- Prior experience working in the fields of oncology and immuno-oncology
- Minimum of 3+ years of relevant work experience for Master's degree applicants and 5+ years for Bachelor's degree applicants
- Demonstration of high-quality scholarly productivity in a relevant field of biomedical research
- Experience in monoplex and multiplex IHC assay development (chromogenic and fluorescence) with comprehension of the underlying principles
- A working knowledge of histology/morphology/pathology interpretation relevant to assay development
- Ability to evaluate and onboard new technologies related to tissue-based biomarker development
- The ability to thrive and self-motivate in an interdisciplinary workplace
- The ability to clearly communicate (verbal and written) scientific objectives, logical experimental design and the analysis and interpretation of data
- Prior experience working in a regulated laboratory setting (CAP/CLIA or other GxP environment) is a plus but not necessary
- Experience with digital scanning and image analysis (HALO, ImageJ, Visiopharm, Inform, Qupath) for H&E, immunohistochemical and multiplexed fluorescence images
- Experience with in-situ nucleic acid hybridization (RNA/DNA) studies on slide-based tissue samples
- Familiarity with assay qualification/validation guidelines and guidance (FDA, CAP, CLIA, NYSDOH, global regulatory requirements for assay development)
- Knowledge of clinical sample handling, analysis and regulatory and quality frameworks and guidance in the lab and at vendors (such as GCP, CLIA, CAP, and NYDOH)
Job description:
- Responsibility for all aspects of assay development including intake, research, planning, development, coordination, execution, risk communication/management, updates and transfer of assays including (but not limited to) chromogenic immunohistochemistry (IHC), in-situ nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology
- Design, organization, and execution of assay development workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues
- Directly responsible for planning, coordination, and execution of assay transfer to vendor sites
- Maintain technical proficiency across several IHC, mIF, histology and digital scanner technologies
- Provide concise yet thorough project overviews and timelines to leadership and stakeholders
- Contribute to design control processes and CAP/CLIA lab work, documentation and planning when needed
- Coordinate and execute clinical trial sample and commercial sample assay development and deployment within BMS labs with appropriate documentation
- Responsible for working on multiple development projects simultaneously with appropriate project prioritization while also participating in lab management and other lab initiatives
- Review and scoring of stained slides with the engagement of pathologist oversight and review as needed
- Responsible for digital image analysis for assay quality assessment and cohort/tissue analysis
- Maintain workplace and lab compliant processes, documentation, and communication
- Mentoring and coaching less experienced scientists
- This is a lab-based position requiring on-site work >80% of the time (averaged across 2 weeks)
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
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