Job Description
Senior Scientist (Protein & Enzyme Analytics) – Data Rich Measurements
Job Description:
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.
As a Senior Scientist in Analytical Enabling Capabilities, you will work with a highly collaborative team to advance the development pipeline. You will be primarily responsible for developing analytical methods for complex small molecules, peptides, oligonucleotides, protein-based therapeutics, and emerging modalities in our portfolio. You will work side by side with process chemists to deploy innovative technologies and analytical workflows for high-throughput analysis and characterization across fast-paced laboratory settings (Method Discovery, Protein Engineering, Biocatalysis). As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.
Education Minimum Requirement:
- PhD in Chemistry or a related field OR
- Masters in Chemistry or related field with 5+ years of experience OR
- Bachelors in Chemistry or related field with 8+ years of experience
Required Experience And Skills:
- 3+ years of thorough understanding of chromatography and mass spectrometry within method development.
- Creative problem solving in scientific research
- Excellent written and verbal communication
- Strong track-record of innovation translated into high impact factor publication
- Bioanalytical techniques, separations and python coding
- LC/MS analysis of proteins/enzymes, HDX-MS and high-throughput analysis
- Enzyme kinetics
Preferred Experience And Skills:
- Expertise in method development and troubleshooting of high-throughput fast chromatographic methods including reversed phase, ion exchange, size exclusion chromatography, etc.
- Hands-on experience in protein characterization techniques such as intact mass analysis, native-MS, peptide mapping analysis for the identification of PTMs, HCPs and disulfide mapping
- Strong understanding of designing and executing enzyme kinetics and functional activity assays
- Willing to learn new technologies and automation
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
AR&D
Required Skills:
Accountability, Accountability, Adaptability, Analytical Method Development, Anion Exchange Chromatography, Assay Development, Bioanalytical Analysis, Biochemical Assays, Cell-Based Assays, Chromatographic Techniques, Column Chromatography, Communication, Enzyme Kinetics, Gas Chromatography-Mass Spectrometry (GC-MS), GMP Environments, Healthcare Innovation, Innovative Thinking, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry (MS), Nuclear Magnetic Resonance (NMR) Analysis, Process Analytical Technology (PAT), Protein Engineering, Proteomics, Scientific Research, Spectrometry {+ 4 more}
Preferred Skills:
Current Employees apply HERE
Current Contingent Workers apply HERE
US And Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As An Equal Employment Opportunity Employer, We Provide Equal Opportunities To All Employees And Applicants For Employment And Prohibit Discrimination On The Basis Of Race, Color, Age, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Protected Veteran Status, Disability Status, Or Other Applicable Legally Protected Characteristics. As a Federal Contractor, We Comply With All Affirmative Action Requirements For Protected Veterans And Individuals With Disabilities. For More Information About Personal Rights Under The U.S. Equal Opportunity Employment Laws, Visit:
EEOC Know Your Rights
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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The salary range for this role is
$117,000.00 - $184,200.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
N/A
Job Posting End Date:
02/20/2026
- A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R384815
