Job Description
Principal Scientist (R5), Quantitative Biosciences, In vivo Pharmacology,
The Discovery Quantitative Biosciences (QB) in vivo Pharmacology team at Boston is looking for an initiative-taking and experienced Principal Scientist with a strong background in Immunology and In Vivo Pharmacology. The successful candidate is expected to drive scientific excellence in the implementation of inflammation/autoimmune model development, in vivo PK/PD and efficacy studies while serving as a key intellectual contributor in the conception and execution of discovery projects. The role will involve significant interaction and collaboration among various functional groups in a highly matrix system and with external partners.
The Successful Candidate Will Lead In Vivo Scientists To
- Perform experiments using preclinical species to support the discovery and clinical development of novel immunology compounds.
- Manage external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines.
- Manage a group of in vivo scientists, providing guidance, mentorship, accountability, and professional development opportunities.
- Serve as a scientific leader in the Quantitative Biosciences (QB) department at Boston, partnering and aligning with our global, network-wide organizational objectives, and ensuring that we remain at the forefront of drug discovery.
- Represent the QB/Pharmacology functional area at therapeutic area governance forums, program teams, due diligence exercises, and/or cross-functional teams as needed.
- Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.
- Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.
Education
- PhD in Immunology, Pharmacology, Biology, Biotechnology, Molecular and Cell Biology, Biochemistry, Bioengineering, or related STEM field with 7+ years of industry / biotech experience in immunology drug discovery, or an MS with 10+ years of experience, or a BS with 14+ years of experience.
Required Skills
- Experience using preclinical models to evaluate the in vivo pharmacology of novel immunology and/or inflammation drugs.
- Proven managerial/supervisory experience with a track record of training, developing talent, and mentoring team members in the field of Immunology/pharmacology and drug discovery.
- Proficiency in complex problem-solving and the ability to influence strategy across organizational boundaries.
- Strong skills in strategic thinking, effective communication, collaboration, balanced risk-taking, and a relentless pursuit of excellence.
#EligibleforERP
Required Skills
Accountability, Adaptability, Assay Development, Autoimmune Diseases, Biopharmaceutical Industry, Cell Culture Techniques, Clinical Immunology, Communication Strategy Development, Detail-Oriented, Drug Discovery Process, Ethical Compliance, Immunology, Immunotherapy, Inflammatory Diseases, Innovation, In Vivo Models, In Vivo Pharmacology, Leading Project Teams, Mouse Models, Persuasion, Translational Pharmacokinetics and Pharmacodynamics (PKPD)
Preferred Skills
Current Employees apply HERE
Current Contingent Workers apply HERE
US And Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
Requirements
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The salary range for this role is
$176,200.00 - $277,300.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status
Regular
Relocation:
Domestic
VISA Sponsorship
Yes
Travel Requirements
10%
Flexible Work Arrangements
Not Applicable
Shift
Not Indicated
Valid Driving License
No
Hazardous Material(s)
Bloodborne pathogens, BSL2, OEB4, OEB5, standard lab reagents
Job Posting End Date
02/6/2026
- A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R382916
