Join a pioneering research team in Cambridge, MA, as a Scientist II focused on the cutting-edge field of microphysiological systems (MPS) and bioprinted models. In this role, you will perform hands-on experimentation to advance biofabrication efforts, creating complex in vitro "organ-on-chip" systems that simulate human biology for drug discovery. This is a highly collaborative, onsite position where you will support the development of 3D models—such as simulated blood vessels—to revolutionize how we study diseases and develop new therapies.
Responsibilities
- Support the biofabrication, setup, and long-term maintenance of microphysiological systems and bioprinted models.
- Perform routine mammalian cell culture while maintaining strict aseptic techniques to ensure culture integrity.
- Prepare and handle specialized hydrogels and extracellular matrices (ECM) for 3D culture platforms.
- Execute multi-step experimental protocols, including immunofluorescence staining and imaging workflows.
- Reconstitute, aliquot, and manage reagents and media to support daily laboratory operations.
- Document all experimental procedures, observations, and data accurately within an Electronic Lab Notebook (ELN).
- Manage laboratory inventory, including ordering supplies and maintaining general lab organization.
- Assist in data analysis and imaging to assess cell health and experimental progress.
- Collaborate across functional teams and locations to support evolving project needs.
- Support general and project-specific operations to ensure a smooth-running laboratory environment.
Education
- Required: B.S./B.A. in Bioengineering, Biology, Biomedical Engineering, Cell & Molecular Biology, Immunology, or a related field with 1–2 years of relevant experience.
- Alternative: M.S. in a related field with 0–1 year of experience.
Experience
- Required: Minimum of 2 years of experience in mammalian cell culture and aseptic technique.
- Technical Proficiency: Proven experience handling biomaterials or hydrogels for 3D applications.
- Specialized Knowledge: Working experience with MPS models, bioprinted platforms, or other 3D cell culture technologies.
- Microscopy: Familiarity with basic microscopy techniques for assessing experimental progress.
- Preferred: Experience with stem cell culture, differentiation workflows, or stem cell-derived organoid models.
- Advantageous: Familiarity with high-throughput platforms (e.g., MIMETAS organ-on-chip) and pharmaceutical drug discovery.
- Data Skills: Experience with data analysis using Matlab, R, or Python is a plus.
Additional Information
- Shift: Supports day-to-day laboratory workflows and deadlines.
- Soft Skills: Requires strong attention to detail, a self-motivated attitude, and an eagerness to learn new biofabrication workflows.
- Collaboration: Must be a proactive team player comfortable working in a fast-paced research environment.
