We are seeking an experienced individual with cancer research and oncology drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist and with the ability to work across a highly matrixed organization to advance programs from target discovery and validation to lead optimization, selection of drug candidate and IND-enabling biology related activities.
This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing various cellular assays to enable compound triaging and identification of potential drug candidates. In addition, the individual will work closely with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others.
In the role as a Scientist within Oncology Discovery Biology, the ideal candidate:
- Applies extensive scientific knowledge and technical skills to conduct molecular and cellular biology related studies to better understand target and disease biology
- Uses current and new technologies for function-based characterization for small molecule hit validation, mechanism of action understanding, and compound triaging/ranking
- Designs and executes experiments independently, troubleshoots as needed, interprets and discusses data, with accurate, timely and detailed record-keeping
- Performs laboratory work related but not limited to 2D/3D/spheroid cell culture and related cellular assays, Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay, processing of DNA/RNA/protein, IP/Co-IP
- Generates and characterizes relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA, lentiviral mediated target overexpression, etc.) and establishing drug-resistant cell lines
- Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science, etc.
- Communicates via email, meetings, and reports
- Makes presentations in small, multidisciplinary meetings, logically presenting data and interpretation to convey clear, key messages
Responsibilities will include but are not limited to the following:
- Design and implementation of high-throughput cell-based reporter assays to characterize drug candidates
- Establish stable cell lines via lentiviral transduction and maintain mammalian cell lines
- Conduct routine molecular and cellular experiments including DNA/RNA/protein extraction, immunoblot analysis, and immunoprecipitation
- Assist senior researchers in executing, conducting analyses, and reporting results of experiments
- Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work
- Analyze, troubleshoot, and recommend corrective actions for routine problems
- Maintain an accurate, comprehensive, and current laboratory notebook
- Write protocols, procedures, and technical reports
- Communicate results via written reports and oral presentations
Qualifications
- BS with 5 years of experience post-graduation or MS.
- Expertise in mammalian cell culture, plate-based cellular assays, immunoblotting, lentiviral infection, cellular transfection, and basic molecular biology techniques
- Experience with medium and high-throughput screening is highly preferred
- Experience with targeted protein degradation assay is a plus
- Familiarity with automation instruments and multi-mode plate readers
- Outstanding problem-solving and organization skills.
- Effective team player and strong individual contributor
- Self-driven, flexible, pragmatic, and able to handle multiple tasks while delivering high quality data
- Effective communication skills, both verbal and written
Working Conditions
Exposure to hazards or disagreeable conditions:
Travel Required
Physical Demands:
Additional Information
Onsite/Hybrid: 100% Onsite
Work Schedule: 9-5 ET
This posting is for a contract assignment with
ASK Staffing DBA ASK Consulting to provide services to
Bristol Myer-Squibb.
The starting hourly compensation for this assignment is the following range ($52- $54.60/hr). While the final, individual compensation and any available benefits will be determined by your employer of record ASK Staffing, Inc (and not BMS), factors that will be included in making the final determination may include the characteristics of the assignment, such as demonstrated experience, required skill, and the geographic location where the job is performed. The starting hourly compensation may be subject to change.
About ASK Consulting
ASK Consulting is an award-winning, woman-owned staffing and recruitment solutions provider with over three decades of industry experience. We specialize in connecting businesses of all sizes?across IT, healthcare, engineering, finance, and more?with top-tier professionals. Backed by a global network and personalized service approach, our team is dedicated to building meaningful partnerships that drive organizational success and empower job seekers to excel in their careers.
Benefits
ASK Consulting provides comprehensive, ACA-compliant health coverage, along with dental, vision, Short- and Long-Term disability for eligible employees. We also offer commuter benefits, a 401(k) plan with no matching, and a referral bonus program. In addition, ASK Consulting offers unpaid leave and paid sick leave as required by law.
Equal Opportunity Employer
ASK Consulting is an equal opportunity employer and does not discriminate against employees or applicants based on race, religion, color, sex, national origin, age, sexual orientation, gender identity, genetic information, disability, veteran status, or any other classification protected by federal, state, or local laws.
California Applicant Notice
ASK Consulting is committed to complying with the California Privacy Rights Act (?CPRA?), effective January 1, 2023, as well as all relevant data privacy laws in the jurisdictions where we recruit and hire. To learn more, please review our Notice to California Job Applicants Regarding the Collection of Personal Information on our website. Applicants with disabilities may request this notice in an alternative format by contactingHR@askconsulting.com.
Fair Chance Employment Notice
If you are selected for a position at, ASK Consulting, your offer is contingent upon successfully meeting several requirements, which may include a criminal background check. In accordance with all applicable federal, state, and local ?Fair Chance? ordinances and laws?such as the Los Angeles County Fair Chance Ordinance (FCO) and the California Fair Chance Act (FCA)?we consider qualified applicants with arrest or conviction records. The background check will evaluate whether any criminal history could reasonably pose a direct, negative impact on job-related safety, security, trust, regulatory compliance, or overall suitability for the role. Findings that raise concerns may result in withdrawal of a conditional job offer.
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This posting does not constitute an offer of employment. All applicants seeking positions in the United States must be legally authorized to work in the United States. Submitting intentionally false or fraudulent information in response to this posting may disqualify you from consideration. Any eventual offer of employment will be considered ?at will,? regardless of the expected assignment duration.
